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Baked salmon fillets, roasted butternut squash, and broccoli straight out of the oven on a sheet pan.

Baked Salmon with Butternut Squash and Broccoli (Sheet Pan Dinner)

This easy 35-minute sheet pan dinner features salmon fillets roasted alongside butternut squash and broccoli. Staggered baking keeps the fish juicy, and the veggies perfectly roasted for a complete, one-pan weeknight meal or easy meal prep.
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Prep Time 10 minutes
Cook Time 25 minutes
Total Time 35 minutes
Course Dinner, Lunch
Servings 4 Servings
Calories 401 kcal

Equipment

  • 12x16 sheet pan

Ingredients
  

  • 4 salmon fillets about 6 ounces each
  • 4 cups fresh butternut squash peeled, and diced into ½-inch cubes
  • 4 cups fresh broccoli florets cut into bite-sized pieces
  • 2 tablespoons olive oil

Spice Mixture

  • 1 ¾ teaspoons salt
  • ½ teaspoon pepper
  • ½ teaspoon granulated garlic
  • teaspoon onion powder
  • ½ teaspoon smoked paprika or regular paprika
  • ½ teaspoon chili powder
  • pinch chipotle powder or cayenne pepper
I always use Kosher salt in my kitchen! If using table salt, start with half the amount and adjust to taste, as it is much "saltier" by volume.

Instructions
 

  • Preheat your oven to 400°F. In a small bowl, mix together the salt, black pepper, granulated garlic, onion powder, smoked paprika, chili powder, and chipotle powder.
  • Place the diced butternut squash and broccoli florets on a large rimmed baking sheet lined with parchment paper. Drizzle with 2 tablespoons of olive oil and sprinkle with 2 teaspoons of the spice mixture. Toss until evenly coated, then spread into a single layer.
  • Roast the vegetables at 400°F for 15 minutes or until the squash is just fork-tender.
  • While the vegetables roast, pat the salmon fillets completely dry with paper towels. Sprinkle the remaining spice mixture evenly over all sides of the fillets.
  • Carefully remove the hot baking sheet from the oven. Push the vegetables aside to create 4 open spaces on the pan. Place the seasoned salmon fillets into the spots, and drizzle a little olive oil over the top of each fillet.
  • Return the sheet pan to the oven and bake for 8 to 10 minutes. Check thinner fillets around the 8-minute mark. Pull the pan when the internal temperature of the salmon reaches 135°F in the thickest part.
  • Let the salmon rest on the hot pan for 3 to 5 minutes. Squeeze fresh lemon over the sheet pan before serving (optional but delicious)! Enjoy!

Notes

  • Substitutions: Sweet potatoes make a great 1:1 swap for butternut squash. Peel and dice them into ½-inch cubes and follow the exact same cooking times. Fresh cauliflower florets can also be swapped for the broccoli.
  • Squash Prep: Keep your squash dice to a ½-inch so it roasts evenly alongside the broccoli without needing extra time.
  • Skin-on Salmon: If using skin-on salmon and you want crispy skin, skip the parchment paper and place the fillets skin-side down directly onto a well-oiled baking sheet.
  • Storage & Reheating: Store leftovers in airtight containers in the refrigerator for up to 3 days. Reheat gently in a 350°F oven or air fryer for 4 to 5 minutes so the salmon stays moist.

Nutrition

Calories: 401kcalCarbohydrates: 23gProtein: 38gFat: 19gSaturated Fat: 3gPolyunsaturated Fat: 5gMonounsaturated Fat: 9gCholesterol: 94mgSodium: 1133mgPotassium: 853mgFiber: 5gSugar: 5gVitamin A: 282IUVitamin C: 111mgCalcium: 134mgIron: 3mg
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